Local C0,αC^{0,\alpha} Estimates for Viscosity Solutions of Neumann-type Boundary Value Problems

In this article, we prove the local $C^{0,\alpha}$ regularity and provide $C^{0,\alpha}$ estimates for viscosity solutions of fully nonlinear, possibly degenerate, elliptic equations associated to linear or nonlinear Neumann type boundary conditions. The interest of these results comes from the fact that they are indeed regularity results (and not only a priori estimates), from the generality of the equations and boundary conditions we are able to handle and the possible degeneracy of the equations we are able to take in account in the case of linear boundary conditions

The evidence for and against astronomical impacts on climate change and mass extinctions: A review

Numerous studies over the past 30 years have suggested there is a causal connection between the motion of the Sun through the Galaxy and terrestrial mass extinctions or climate change. Proposed mechanisms include comet impacts (via perturbation of the Oort cloud), cosmic rays and supernovae, the effects of which are modulated by the passage of the Sun through the Galactic midplane or spiral arms. Supposed periodicities in the fossil record, impact cratering dates or climate proxies over the Phanerozoic (past 545 Myr) are frequently cited as evidence in support of these hypotheses. This remains a controversial subject, with many refutations and replies having been published. Here I review both the mechanisms and the evidence for and against the relevance of astronomical phenomena to climate change and evolution. This necessarily includes a critical assessment of time series analysis techniques and hypothesis testing. Some of the studies have suffered from flaws in methodology, in particular drawing incorrect conclusions based on ruling out a null hypothesis. I conclude that there is little evidence for intrinsic periodicities in biodiversity, impact cratering or climate on timescales of tens to hundreds of Myr. Furthermore, Galactic midplane and spiral arm crossings seem to have little or no impact on biological or climate variation above background level. (truncated)Comment: 51 pages, 7 figures, 140 references. To appear in the International Journal of Astrobiology. For hyperref version with full resolution figures see http://www.mpia-hd.mpg.de/homes/calj/astimpact_ija.pd

Epstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression

Lytic replication of the human gamma herpes virus Epstein-Barr virus (EBV) is an essential prerequisite for the spread of the virus. Differential regulation of a limited number of cellular genes has been reported in B-cells during the viral lytic replication cycle. We asked whether a viral bZIP transcription factor, Zta (BZLF1, ZEBRA, EB1), drives some of these changes. Using genome-wide chromatin immunoprecipitation coupled to next-generation DNA sequencing (ChIP-seq) we established a map of Zta interactions across the human genome. Using sensitive transcriptome analyses we identified 2263 cellular genes whose expression is significantly changed during the EBV lytic replication cycle. Zta binds 278 of the regulated genes and the distribution of binding sites shows that Zta binds mostly to sites that are distal to transcription start sites. This differs from the prevailing view that Zta activates viral genes by binding exclusively at promoter elements. We show that a synthetic Zta binding element confers Zta regulation at a distance and that distal Zta binding sites from cellular genes can confer Zta-mediated regulation on a heterologous promoter. This leads us to propose that Zta directly reprograms the expression of cellular genes through distal elements

A prospective study to assess the value of MMP-9 in improving the appropriateness of urgent referrals for colorectal cancer

Background Bowel cancer is common and is a major cause of death. Most people with bowel symptoms who meet the criteria for urgent referral to secondary care will not be found to have bowel cancer, and some people who are found to have cancer will have been referred routinely rather than urgently. If general practitioners could better identify people who were likely to have bowel cancer or conditions that may lead to bowel cancer, the pressure on hospital clinics may be reduced, enabling these patients to be seen more quickly. Increased levels of an enzyme called matrix metalloproteinase 9 (MMP-9) have been found to be associated with such conditions, and this can be measured from a blood sample. This study aims to find out whether measuring MMP-9 levels could improve the appropriateness of urgent referrals for patients with bowel symptoms. Methods People aged 18 years or older referred to a colorectal clinic will be asked to complete a questionnaire about symptoms, recent injuries or chronic illnesses (these can increase the level of matrix metalloproteinases) and family history of bowel cancer. A blood sample will be taken from people who consent to take part to assess MMP-9 levels, and the results of examination at the clinic and/or investigations arising from the clinic visit will be collected from hospital records. The accuracy of MMP-9 will be assessed by comparing the MMP-9 level with the resulting diagnosis. The combination of factors (e.g. symptoms and MMP-9 level) that best predict a diagnosis of malignancy (invasive disease or polyps) will be determined. Discussion Although guidelines are in place to facilitate referrals to colorectal clinics, symptoms alone do not adequately distinguish people with malignancy from people with benign conditions. This study will establish whether MMP-9 could assist this process. If this were the case, measurement of MMP-9 levels could be used by general practitioners to assist in the identification of people who were most likely to have bowel cancer or conditions that may lead to bowel cancer, and who should, therefore, be referred most urgently to secondary car

Virtual Assistants for End-User Development in the Internet of Things

The spread of Virtual Assistants (software and hardware) on the consumer market deeply changed the way Internet of Things (IoT) is implemented and used today. Such devices, and related applications, are becoming more and more integrated within smart environments and this might pave the way to potential new approaches to End-User Development activities, which can be performed in IoT environments. This paper discusses the evolution of the IoT ecosystem definition that has been studied by the authors in the last years

Aerobic capacity, activity levels and daily energy expenditure in male and female adolescents of the kenyan nandi sub-group

The relative importance of genetic and socio-cultural influences contributing to the success of east Africans in endurance athletics remains unknown in part because the pre-training phenotype of this population remains incompletely assessed. Here cardiopulmonary fitness, physical activity levels, distance travelled to school and daily energy expenditure in 15 habitually active male (13.9±1.6 years) and 15 habitually active female (13.9±1.2) adolescents from a rural Nandi primary school are assessed. Aerobic capacity ([Formula: see text]) was evaluated during two maximal discontinuous incremental exercise tests; physical activity using accelerometry combined with a global positioning system; and energy expenditure using the doubly labelled water method. The [Formula: see text] of the male and female adolescents were 73.9±5.7 ml(.) kg(-1.) min(-1) and 61.5±6.3 ml(.) kg(-1.) min(-1), respectively. Total time spent in sedentary, light, moderate and vigorous physical activities per day was 406±63 min (50% of total monitored time), 244±56 min (30%), 75±18 min (9%) and 82±30 min (10%). Average total daily distance travelled to and from school was 7.5±3.0 km (0.8-13.4 km). Mean daily energy expenditure, activity-induced energy expenditure and physical activity level was 12.2±3.4 MJ(.) day(-1), 5.4±3.0 MJ(.) day(-1) and 2.2±0.6. 70.6% of the variation in [Formula: see text] was explained by sex (partial R(2) = 54.7%) and body mass index (partial R(2) = 15.9%). Energy expenditure and physical activity variables did not predict variation in [Formula: see text] once sex had been accounted for. The highly active and energy-demanding lifestyle of rural Kenyan adolescents may account for their exceptional aerobic fitness and collectively prime them for later training and athletic success

A AULA DE EDUCAÇÃO FÍSICA E A INCLUSÃO DA CRIANÇA COM DEFICIÊNCIA: PERSPECTIVA DE PROFESSORES BRASILEIROS

This study analyzed Physical Education teachers’ concept of inclusion and determined positive and negative aspects of inclusion in their classes. Interviews were conducted with 18 Physical Education teachers working in Brazilian public schools. Data collected were examined by content analysis to search for emerging themes. The findings showed that inclusion was understood as participation and learning for all children rather than only for those with disabilities. Team sports were pointed as the main challenge for the inclusion of students with disability. Initial and continuing education programs for teachers need to target effective pedagogical practices to promote inclusion, leading to restructuring Physical Education teachers’ training.   Los objetivos de este estudio fueron analizar concepto de inclusión profesores de educación física 'y determinar los aspectos positivos y negativos de la inclusión en sus clases. Se realizó una entrevista con 18 profesores de educación física que trabaja en las escuelas públicas brasileñas. Los datos recogidos fueron analizados utilizando el método de análisis de contenido, búsqueda de temas emergentes. Los resultados mostraron que la inclusión se entiende como la participación y el aprendizaje de todos los niños y no sólo para las personas con una discapacidad. Los deportes de equipo se informaron como un reto importante para la inclusión de los estudiantes con discapacidad. los programas de educación inicial y continua para los profesores tienen que orientar las prácticas pedagógicas efectivas para promover la inclusión, dando lugar a la reestructuración de la formación de profesores de educación física. O estudo teve como objetivo analisar o conceito de inclusão dos professores de Educação Física e determinar os aspectos positivos e negativos em suas aulas. Foram realizadas entrevistas com 18 professores de Educação Física que trabalham em escolas públicas brasileiras. Os dados coletados foram analisados utilizando-se o método de análise de conteúdo, em busca de temas emergentes. Os resultados mostraram que a inclusão é compreendida pelos professores como participação e aprendizagem para todas as crianças e não apenas para aqueles com deficiência. Os esportes coletivos foram relatados como o principal desafio para a inclusão de alunos com deficiência. Programas de formação inicial e de capacitação continuada para os professores precisam propor práticas pedagógicas eficazes para promover a inclusão, levando a reestruturação da formação de professores de Educação Física.

On the regularity up to the boundary for certain nonlinear elliptic systems

We consider a class of nonlinear elliptic systems and we prove regularity up to the boundary for second order derivatives. In the proof we trace carefully the dependence on the various parameters of the problem, in order to establish, in a further work, results for more general systems

The value of age and medical history for predicting colorectal cancer and adenomas in people referred for colonoscopy

<p>Abstract</p> <p>Background</p> <p>Colonoscopy is an invasive and costly procedure with a risk of serious complications. It would therefore be useful to prioritise colonoscopies by identifying people at higher risk of either cancer or premalignant adenomas. The aim of this study is to assess a model that identifies people with colorectal cancer, advanced, large and small adenomas.</p> <p>Methods</p> <p>Patients seen by gastroenterologists and colorectal surgeons between April 2004 and December 2006 completed a validated, structured self-administered questionnaire prior to colonoscopy. Information was collected on symptoms, demographics and medical history. Multinomial logistic regression was used to simultaneously assess factors associated with findings on colonoscopy of cancer, advanced adenomas and adenomas sized 6 -9 mm, and ≤ 5 mm. The area under the curve of ROC curve was used to assess the incremental gain of adding demographic variables, medical history and symptoms (in that order) to a base model that included only age.</p> <p>Results</p> <p>Sociodemographic variables, medical history and symptoms (from 8,204 patients) jointly provide good discrimination between colorectal cancer and no abnormality (AUC 0.83), but discriminate less well between adenomas and no abnormality (AUC advanced adenoma 0.70; other adenomas 0.67). Age is the dominant risk factor for cancer and adenomas of all sizes. Having a colonoscopy within the last 10 years confers protection for cancers and advanced adenomas.</p> <p>Conclusions</p> <p>Our models provide guidance about which factors can assist in identifying people at higher risk of disease using easily elicited information. This would allow colonoscopy to be prioritised for those for whom it would be of most benefit.</p